COL2A1

Across TCGA pan-cancer cohorts, COL2A1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated COL2A1 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher COL2A1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL2A1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and UVM show a favorable association.

ACC, PAAD, and UVM are the cancer types where COL2A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.208	0.658	<.001	89	view →
PAAD	OS	Quartile	All	0.696	0.411	<.001	60	view →
UVM	DFS	Quartile	III,IV	1.000	0.436	.003	52	view →
KIRC	DFS	Tertile	IV	0.222	0.610	<.001	51	view →
BLCA	DFS	Tertile	III,IV	0.188	0.347	.009	39	view →
THCA	DFS	Median	II,III,IV	0.780	0.941	.002	29	view →
MESO	OS	Median	II,III,IV	0.201	0.387	.009	23	view →
LAML	DFS	Quartile	All	0.723	0.467	.011	18	view →
LGG	OS	Tertile	All	0.722	0.864	<.001	17	view →
KIRP	DFS	Quartile	All	0.328	0.735	.007	13	view →
UCS	OS	Tertile	IV	0.296	0.665	.024	12	view →
BRCA	DFS	Quartile	III,IV	0.874	0.714	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

COL2A1–ACC (DFS)

Open the ACC breakdown →