COL26A1

Across TCGA patient cohorts, COL26A1 mutation is significantly associated with the RNA expression of many other genes, with 729 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL26A1-associated genes across cancer lineages are EEF1E1-BLOC1S5, CICP28, and AIMP1. Each is linked with COL26A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COL26A1-to-partner and partner-to-COL26A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF1E1-BLOC1S5 grouped by COL26A1-low versus COL26A1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL26A1→partner) and Y-score (partner→COL26A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EEF1E1-BLOC1S5 →	+0.063	+5.124	<.001	.008	3	3
CESC	CICP28 →	+0.015	+5.010	<.001	.009	3	2
UCEC	AIMP1 →	+0.597	+3.499	<.001	.002	3	2
SKCM	NOL12 →	+0.534	+3.208	.001	.009	3	2
CESC	GSTA6P →	+0.086	+5.010	.003	.009	3	2
HNSC	IGHVII-15-1 →	+0.219	+7.132	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 729 associations by consensus.

EEF1E1-BLOC1S5 by COL26A1 expression — HNSC

Explore this box plot interactively →