COL26A1

Across TCGA pan-cancer cohorts, COL26A1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated COL26A1 data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher COL26A1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated COL26A1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and SCLC show a favorable association.

UVM, MESO, and KIRC are the cancer types where COL26A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.381	0.729	<.001	121	view →
MESO	OS	Tertile	II,III,IV	0.194	0.482	<.001	111	view →
KIRC	DFS	Median	All	0.553	0.695	<.001	83	view →
PAAD	OS	Median	All	0.704	0.519	.001	66	view →
SCLC	DFS	Quartile	III,IV	0.797	0.237	.001	66	view →
ACC	DFS	Median	All	0.289	0.635	<.001	53	view →
LGG	OS	Median	All	0.862	0.756	<.001	51	view →
UCS	OS	Median	III,IV	0.648	0.264	.001	30	view →
DLBC	DFS	Tertile	All	0.932	0.354	.005	28	view →
THCA	OS	Median	All	0.890	0.981	.004	23	view →
KIRP	DFS	Tertile	II,III,IV	0.813	0.508	.015	20	view →
LIHC	DFS	Tertile	All	0.332	0.206	.005	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

COL26A1–UVM (DFS)

Open the UVM breakdown →