COL17A1

Across TCGA patient cohorts, COL17A1 mutation is significantly associated with the RNA expression of many other genes, with 6,534 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COL17A1-associated genes across cancer lineages are ZNF367, TYMSOS, and IER3IP1. Each is linked with COL17A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both COL17A1-to-partner and partner-to-COL17A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF367 grouped by COL17A1-low versus COL17A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COL17A1→partner) and Y-score (partner→COL17A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF367 →	+0.813	+2.584	<.001	<.001	3	4
STAD	TYMSOS →	+0.812	+2.717	<.001	.003	3	4
UCEC	IER3IP1 →	+0.389	+1.678	<.001	<.001	3	4
STAD	APCDD1 →	-1.133	-2.700	.006	.006	3	4
OV	MIR5787 →	+0.699	+4.259	<.001	.001	3	3
LIHC	TRAJ46 →	+0.459	+6.902	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,534 associations by consensus.

ZNF367 by COL17A1 expression — UCEC

Explore this box plot interactively →