COL17A1

Across TCGA pan-cancer cohorts, COL17A1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of COL17A1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where COL17A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COL17A1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

LUAD, HNSC, and THCA are the cancer types where COL17A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COL17A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+3.231	<.001	9	view →
HNSC	Female	III,IV	+2.595	<.001	9	view →
THCA	All	II,III,IV	−1.486	<.001	9	view →
LUSC	Female	II,III,IV	+4.662	<.001	8	view →
COAD	Female	II,III,IV	−2.354	<.001	8	view →
BRCA	Female	All	−3.476	<.001	6	view →
UCEC	All	III,IV	+1.843	.012	6	view →
KIRP	Male	All	+1.224	<.001	6	view →
KICH	All	All	−0.481	<.001	5	view →
PAAD	Female	All	+6.325	.007	4	view →
READ	Male	All	−2.493	.032	3	view →
PRAD	All	All	−1.846	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

COL17A1–LUAD

Open the LUAD breakdown →