COIL

Across TCGA patient cohorts, COIL mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COIL-associated genes across cancer lineages are ERK2, BRCA2, and Caspase-7-cleavedD198. Each is linked with COIL in more than 1 cancer types. Because this analysis shows association rather than direction, both COIL-to-partner and partner-to-COIL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by COIL-low versus COIL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COIL→partner) and Y-score (partner→COIL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.233	+3.169	.027	.020	3	1
UCEC	BRCA2 →	-0.158	-3.162	.023	.019	2	1
UCEC	Caspase-7-cleavedD198 →	+0.977	+3.169	.002	.020	1	2
UCEC	4E-BP1 →	+0.401	+3.169	.006	.020	1	1
UCEC	Cyclin-B1 →	+0.688	+3.169	.025	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ERK2 by COIL expression — UCEC

Explore this box plot interactively →