COIL

Across TCGA pan-cancer cohorts, COIL RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated COIL data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher COIL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated COIL expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

KIRP, LIHC, and UCS are the cancer types where COIL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.748	0.929	.001	104	view →
LIHC	OS	Median	All	0.596	0.774	<.001	74	view →
UCS	OS	Tertile	II,III,IV	0.769	0.218	<.001	72	view →
KIRC	DFS	Quartile	II,III,IV	0.848	0.485	.001	44	view →
ACC	DFS	Tertile	All	0.491	0.831	.001	33	view →
KICH	DFS	Median	III,IV	0.374	0.901	.009	26	view →
SCLC	OS	Tertile	All	0.504	1.000	.007	24	view →
BRCA	DFS	Median	III,IV	0.857	0.729	.004	23	view →
CESC	DFS	Median	III,IV	0.203	0.667	.004	22	view →
UVM	DFS	Tertile	III,IV	0.279	0.780	.017	20	view →
READ	OS	Median	IV	0.878	0.511	.008	15	view →
ESCA	DFS	Tertile	II,III,IV	1.000	0.368	.022	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

COIL–KIRP (DFS)

Open the KIRP breakdown →