COG1

Across TCGA patient cohorts, COG1 protein abundance is significantly associated with the protein abundance of many other proteins, with 18,300 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible COG1-associated proteins across cancer lineages are COG3, COG4, and COG5. Each is linked with COG1 in more than 9 cancer types. Because this analysis shows association rather than direction, both COG1-to-partner and partner-to-COG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COG1 versus COG3 in BRCA, with a Pearson correlation of 0.84.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (COG1→partner) and Y-score (partner→COG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COG3 →	+0.472	+0.445	<.001	<.001	3	10
BRCA	COG4 →	+0.476	+0.485	<.001	<.001	3	10
BRCA	COG5 →	+0.435	+0.465	<.001	<.001	3	10
BRCA	COG6 →	+0.403	+0.389	<.001	<.001	3	10
BRCA	COG7 →	+0.419	+0.430	<.001	<.001	3	10
BRCA	PDXDC1 →	+0.503	+0.277	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,300 associations by consensus.

COG1 vs COG3 — BRCA

Explore this scatter interactively →