COG1

Across TCGA pan-cancer cohorts, COG1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of COG1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where COG1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COG1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, LIHC, and LUAD are the cancer types where COG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.610	<.001	11	view →
LIHC	Female	II,III,IV	+1.143	<.001	9	view →
LUAD	All	II,III,IV	+0.582	<.001	9	view →
KIRC	Female	All	+0.427	<.001	8	view →
HNSC	All	All	+0.412	<.001	7	view →
BRCA	All	III,IV	+0.355	.006	6	view →
CHOL	Male	All	+1.850	<.001	5	view →
THCA	Male	III,IV	−0.389	.012	5	view →
KICH	Female	All	−0.585	<.001	3	view →
BLCA	All	All	+0.371	.024	3	view →
STAD	Male	II,III,IV	+0.578	.020	2	view →
UCEC	All	All	−0.318	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

COG1–KIRP

Open the KIRP breakdown →