COG1

Across TCGA cell cohorts, COG1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COG1-associated genes across cancer lineages are OR2T35, FABP9, and GKN1. Each is linked with COG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COG1-to-partner and partner-to-COG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T35 grouped by COG1-low versus COG1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COG1→partner) and Y-score (partner→COG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR2T35 →	+0.020	+5.614	<.001	.002	3	1
PANCREAS	FABP9 →	+0.073	+5.614	<.001	.002	3	1
BLOOD_Myeloma	GKN1 →	+0.026	+4.807	<.001	.006	3	1
CNS	OR4E1 →	+0.099	+5.321	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	1
BLOOD_Leukemia	S100A7 →	+0.279	+3.885	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR2T35 by COG1 expression — PANCREAS

Explore this box plot interactively →