COCH

Across TCGA patient cohorts, COCH mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COCH-associated genes across cancer lineages are SETD2, JNK_pT183_Y185, and Caspase-7-cleavedD198. Each is linked with COCH in more than 1 cancer types. Because this analysis shows association rather than direction, both COCH-to-partner and partner-to-COCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SETD2 grouped by COCH-low versus COCH-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COCH→partner) and Y-score (partner→COCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SETD2 →	-0.184	-3.321	.013	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.165	-2.906	.005	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.574	+2.000	.006	.003	3	2
UCEC	Caspase-8 →	-0.234	-1.662	.008	.011	3	2
UCEC	c-Met_pY1235 →	+0.089	+2.594	<.001	<.001	3	2
SKCM	14-3-3_beta →	-0.164	-3.000	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

SETD2 by COCH expression — SKCM

Explore this box plot interactively →