COCH

Across TCGA pan-cancer cohorts, COCH RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated COCH data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher COCH RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated COCH expression acts as an unfavorable survival marker, although some lineages such as LUSC and BRCA show a favorable association.

UVM, STAD, and ACC are the cancer types where COCH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.399	0.749	<.001	129	view →
STAD	DFS	Median	All	0.259	0.490	.001	55	view →
ACC	DFS	Quartile	II,III,IV	0.288	0.750	.003	49	view →
LUSC	OS	Median	II,III,IV	0.812	0.670	.002	38	view →
BRCA	DFS	Quartile	All	0.971	0.918	.001	36	view →
KIRC	OS	Tertile	All	0.575	0.725	.005	32	view →
ESCA	DFS	Tertile	III,IV	0.325	0.665	.003	24	view →
LGG	OS	Quartile	All	0.830	0.934	.001	16	view →
SARC	OS	Tertile	All	0.778	0.890	.002	15	view →
OV	OS	Tertile	IV	0.578	0.302	.010	12	view →
READ	OS	Quartile	All	1.000	0.754	.013	12	view →
DLBC	DFS	Tertile	All	0.695	1.000	.012	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

COCH–UVM (DFS)

Open the UVM breakdown →