COCH

Across TCGA pan-cancer cohorts, COCH RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of COCH’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where COCH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types COCH is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

LUAD, KIRC, and THCA are the cancer types where COCH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COCH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+2.871	<.001	11	view →
KIRC	Male	All	−0.918	<.001	9	view →
THCA	All	All	−0.290	<.001	8	view →
LIHC	Female	All	+1.459	<.001	7	view →
HNSC	All	II,III,IV	+0.834	.004	7	view →
LUSC	Male	II,III,IV	+2.090	<.001	6	view →
BLCA	All	All	+1.553	<.001	6	view →
COAD	Male	All	+0.863	<.001	5	view →
STAD	All	All	+0.724	.001	5	view →
ESCA	All	All	+1.444	.010	4	view →
KICH	All	All	+1.245	.003	3	view →
KIRP	All	All	−0.678	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

COCH–LUAD

Open the LUAD breakdown →