CNTN4

Across TCGA patient cohorts, CNTN4 mutation is significantly associated with the total protein of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTN4-associated genes across cancer lineages are GAPDH, EGFR_pY1068, and PR. Each is linked with CNTN4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CNTN4-to-partner and partner-to-CNTN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by CNTN4-low versus CNTN4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTN4→partner) and Y-score (partner→CNTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.710	+2.123	<.001	.010	3	4
COAD	EGFR_pY1068 →	-0.332	-3.000	.010	.034	3	4
UCEC	PR →	-0.147	-1.247	.018	.038	3	4
BLCA	ACVRL1 →	-0.228	-3.152	.021	.019	3	3
STAD	TFRC →	+0.670	+3.321	.008	.009	2	4
COAD	eEF2 →	+0.337	+2.459	.003	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

GAPDH by CNTN4 expression — COAD

Explore this box plot interactively →