CNTN4

Across TCGA pan-cancer cohorts, CNTN4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CNTN4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CNTN4 RNA is repressed in tumor relative to normal tissue. In most cancer types CNTN4 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and UCEC are the cancer types where CNTN4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNTN4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.644	<.001	11	view →
KICH	All	III,IV	−1.450	<.001	10	view →
UCEC	All	All	−1.742	<.001	8	view →
LUSC	Female	II,III,IV	−1.262	<.001	8	view →
LUAD	Female	III,IV	−1.221	<.001	8	view →
THCA	All	II,III,IV	−0.850	<.001	8	view →
BLCA	All	All	−0.905	.001	7	view →
KIRC	All	II,III,IV	−0.480	.001	6	view →
READ	Female	All	−1.426	<.001	5	view →
BRCA	All	All	−0.573	<.001	4	view →
HNSC	Male	All	−0.460	.008	4	view →
LIHC	Male	All	−0.292	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CNTN4–COAD

Open the COAD breakdown →