CNTN4

Across TCGA pan-cancer cohorts, CNTN4 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated CNTN4 data layer compared with 9 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher CNTN4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CNTN4 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCEC show a favorable association.

LGG, UCEC, and KIRC are the cancer types where CNTN4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.472	0.287	<.001	48	view →
UCEC	DFS	Quartile	II,III,IV	0.943	0.737	<.001	40	view →
KIRC	DFS	Median	IV	0.512	0.219	.001	34	view →
OV	DFS	Quartile	II,III,IV	0.306	0.431	.003	32	view →
CHOL	DFS	Tertile	All	0.763	0.230	.005	29	view →
SCLC	DFS	Median	All	0.374	0.589	.009	27	view →
MESO	OS	Median	IV	0.804	0.302	<.001	27	view →
PAAD	OS	Median	II,III,IV	0.442	0.312	.010	20	view →
STAD	DFS	Median	All	0.481	0.621	.004	20	view →
KIRP	DFS	Quartile	All	0.974	0.851	.007	16	view →
CESC	OS	Quartile	All	0.867	0.713	.010	12	view →
ESCA	DFS	Quartile	All	0.478	0.211	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

CNTN4–LGG (DFS)

Open the LGG breakdown →