CNTF

Across TCGA patient cohorts, CNTF mutation is significantly associated with the RNA expression of many other genes, with 340 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTF-associated genes across cancer lineages are FAM230F, OR7E162P, and TP73-AS2. Each is linked with CNTF in more than 1 cancer types. Because this analysis shows association rather than direction, both CNTF-to-partner and partner-to-CNTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM230F grouped by CNTF-low versus CNTF-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTF→partner) and Y-score (partner→CNTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	FAM230F →	+0.084	+7.640	<.001	.009	3	1
SKCM	OR7E162P →	+0.096	+4.595	<.001	.004	3	1
SKCM	TP73-AS2 →	+0.205	+4.628	<.001	.004	3	1
SKCM	LINC01808 →	+0.079	+6.219	<.001	<.001	3	1
SKCM	RNA5SP162 →	+0.546	+5.797	<.001	.001	3	1
SKCM	RNU2-45P →	+0.152	+5.199	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 340 associations by consensus.

FAM230F by CNTF expression — BLCA

Explore this box plot interactively →