CNTF

Across TCGA pan-cancer cohorts, CNTF RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CNTF data layer compared with 7 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CNTF RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CNTF expression acts as an unfavorable survival marker, although some lineages such as READ and UCS show a favorable association.

ACC, MESO, and UVM are the cancer types where CNTF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	III,IV	0.132	0.769	<.001	84	view →
MESO	OS	Quartile	All	0.328	0.640	<.001	67	view →
UVM	DFS	Median	II,III,IV	0.432	0.758	<.001	62	view →
READ	DFS	Quartile	II,III,IV	1.000	0.450	.003	62	view →
KICH	OS	Quartile	All	0.594	1.000	.002	59	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
PAAD	OS	Median	All	0.272	0.512	.004	31	view →
BLCA	DFS	Quartile	All	0.203	0.599	.005	28	view →
STAD	DFS	Tertile	IV	0.257	0.792	.007	27	view →
KIRC	DFS	Tertile	II,III,IV	0.730	0.895	.005	26	view →
CESC	DFS	Quartile	All	0.748	0.896	.011	26	view →
LUAD	OS	Median	II,III,IV	0.562	0.346	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CNTF–ACC (OS)

Open the ACC breakdown →