CNTF

Across TCGA pan-cancer cohorts, CNTF RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CNTF’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where CNTF RNA is repressed in tumor relative to normal tissue. In most cancer types CNTF is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.

BRCA, LIHC, and CHOL are the cancer types where CNTF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNTF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.358	.006	8	view →
LIHC	Male	All	+0.286	<.001	6	view →
CHOL	All	All	+0.653	.008	4	view →
STAD	All	II,III,IV	+0.338	.011	4	view →
KIRC	Male	III,IV	−0.242	.009	4	view →
THCA	All	IV	−0.392	.018	3	view →
KICH	All	All	−0.269	.011	2	view →
ESCA	All	All	+0.336	.029	1	view →
HNSC	Male	II,III,IV	+0.206	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CNTF–BRCA

Open the BRCA breakdown →