CNTF

Across TCGA patient cohorts, CNTF mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTF-associated genes across cancer lineages are eIF4G, MEK1_p_S217_S221, and Myosin-IIa_pS1943. Each is linked with CNTF in more than 1 cancer types. Because this analysis shows association rather than direction, both CNTF-to-partner and partner-to-CNTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by CNTF-low versus CNTF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTF→partner) and Y-score (partner→CNTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.362	+3.000	.026	.036	3	1
UCEC	MEK1_p_S217_S221 →	-0.327	-3.000	.022	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.276	+3.335	.010	.005	3	1
UCEC	Rictor_pT1135 →	-0.127	-2.999	.017	.035	3	1
UCEC	STAT3_pY705 →	-0.509	-3.169	<.001	.018	3	1
UCEC	Cyclin-E2 →	+0.198	+3.321	.024	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eIF4G by CNTF expression — UCEC

Explore this box plot interactively →