CNTF

Across TCGA cell cohorts, CNTF RNA expression is significantly associated with the go_rna of many other GO terms, with 4,242 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNTF-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Subtelomeric heterochromatin formation, and Centrosome duplication. Each is linked with CNTF in more than 14 cancer types. Because this analysis shows association rather than direction, both CNTF-to-partner and partner-to-CNTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by CNTF-low versus CNTF-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTF→partner) and Y-score (partner→CNTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.111	+0.459	.006	.003	3	15
BREAST	Subtelomeric heterochromatin formation →	+0.112	+0.625	<.001	<.001	3	15
BONE	Centrosome duplication →	+0.129	+0.679	<.001	<.001	3	15
LUNG_SCLC	Centrosome cycle →	+0.093	+0.847	<.001	<.001	3	15
BONE	Centriole replication →	+0.123	+0.656	.001	<.001	3	15
SOFT_TISSUE	Double-strand break repair via nonhomologous end joining →	+0.055	+0.682	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,242 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by CNTF expression — STOMACH

Explore this box plot interactively →