CNTF

Across TCGA cell cohorts, CNTF mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CNTF-associated genes across cancer lineages are LYZL2, KRTAP6-1, and C16orf90. Each is linked with CNTF in more than 1 cancer types. Because this analysis shows association rather than direction, both CNTF-to-partner and partner-to-CNTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL2 grouped by CNTF-low versus CNTF-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTF→partner) and Y-score (partner→CNTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LYZL2 →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	KRTAP6-1 →	+0.052	+4.643	<.001	.004	3	1
LUNG_SCLC	C16orf90 →	+0.061	+4.044	<.001	.009	3	1
LUNG_SCLC	KIR3DL2 →	+0.407	+4.817	.004	.001	3	1
LUNG_SCLC	ASIC5 →	+0.081	+4.269	<.001	.005	3	1
STOMACH	CCDC182 →	+0.033	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

LYZL2 by CNTF expression — LUNG_SCLC

Explore this box plot interactively →