CNST

Across TCGA patient cohorts, CNST mutation is significantly associated with the RNA expression of many other genes, with 1,066 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNST-associated genes across cancer lineages are TUBGCP4, RN7SKP214, and PSMC3IP. Each is linked with CNST in more than 2 cancer types. Because this analysis shows association rather than direction, both CNST-to-partner and partner-to-CNST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBGCP4 grouped by CNST-low versus CNST-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNST→partner) and Y-score (partner→CNST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBGCP4 →	+0.418	+2.058	<.001	<.001	3	3
UCEC	RN7SKP214 →	+0.137	+1.472	.005	.009	3	3
SKCM	PSMC3IP →	+0.573	+2.757	.003	.003	3	3
COAD	SNORD114-13 →	+0.487	+4.335	<.001	.005	3	2
COAD	SNORD114-6 →	+0.601	+4.109	<.001	.007	3	2
COAD	SNORD114-17 →	+0.715	+4.602	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,066 associations by consensus.

TUBGCP4 by CNST expression — UCEC

Explore this box plot interactively →