CNST

Across TCGA pan-cancer cohorts, CNST RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CNST’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CNST RNA is repressed in tumor relative to normal tissue. In most cancer types CNST is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KICH are the cancer types where CNST tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNST RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.261	<.001	11	view →
COAD	Female	All	−0.886	<.001	10	view →
KICH	Female	All	−1.508	<.001	8	view →
BLCA	Male	IV	−1.270	.003	7	view →
BRCA	All	II,III,IV	+0.474	<.001	6	view →
LIHC	Male	All	+0.626	<.001	4	view →
HNSC	All	II,III,IV	+0.350	.016	4	view →
ESCA	All	II,III,IV	−0.789	.007	2	view →
READ	All	All	−0.737	.002	2	view →
LUAD	Female	II,III,IV	−0.542	.005	2	view →
KIRP	Male	All	−0.498	.001	2	view →
UCEC	All	All	−0.478	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CNST–THCA

Open the THCA breakdown →