CNPY4

Across TCGA patient cohorts, CNPY4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNPY4-associated genes across cancer lineages are EGFR_pY1068, IGFBP2, and Ku80. Each is linked with CNPY4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNPY4-to-partner and partner-to-CNPY4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CNPY4-low versus CNPY4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNPY4→partner) and Y-score (partner→CNPY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.276	-3.459	.028	.005	3	1
UCEC	IGFBP2 →	-0.663	-2.321	.042	.035	3	1
UCEC	Ku80 →	+0.355	+3.472	.002	.002	3	1
UCEC	Myosin-IIa_pS1943 →	+0.285	+3.472	.005	.002	3	1
UCEC	p62 Lck ligand →	+0.574	+3.459	<.001	.005	3	1
UCEC	PDK1_pS241 →	+0.173	+2.335	.043	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by CNPY4 expression — UCEC

Explore this box plot interactively →