CNPY4

Across TCGA pan-cancer cohorts, CNPY4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CNPY4 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher CNPY4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CNPY4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUAD show a favorable association.

MESO, KIRP, and LIHC are the cancer types where CNPY4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.275	0.557	<.001	108	view →
KIRP	DFS	Quartile	III,IV	0.128	0.653	<.001	68	view →
LIHC	OS	Median	All	0.429	0.598	<.001	64	view →
BLCA	OS	Quartile	All	0.555	0.761	<.001	63	view →
LGG	OS	Median	All	0.338	0.556	<.001	50	view →
KIRC	DFS	Median	III,IV	0.645	0.303	.001	34	view →
COAD	DFS	Tertile	All	0.309	0.577	.002	29	view →
LUSC	DFS	Tertile	III,IV	0.348	0.634	.008	24	view →
LUAD	OS	Median	II,III,IV	0.629	0.483	.006	23	view →
THYM	OS	Median	II,III,IV	0.975	0.661	.004	20	view →
ESCA	OS	Median	All	1.000	0.629	.012	17	view →
ACC	OS	Median	IV	0.344	0.724	.038	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CNPY4–MESO (OS)

Open the MESO breakdown →