CNPY4

Across TCGA pan-cancer cohorts, CNPY4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CNPY4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CNPY4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CNPY4 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where CNPY4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNPY4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.228	<.001	12	view →
KIRC	Male	IV	+0.722	<.001	10	view →
KICH	Female	All	−1.850	<.001	8	view →
LIHC	Female	II,III,IV	+1.204	<.001	8	view →
BRCA	All	All	+0.238	<.001	8	view →
CHOL	Male	All	+2.173	<.001	5	view →
COAD	Female	II,III,IV	−0.446	.004	5	view →
LUSC	All	II,III,IV	+0.379	.011	3	view →
ESCA	Male	All	+1.264	.018	2	view →
KIRP	All	IV	+1.084	.009	2	view →
PRAD	All	All	−0.630	<.001	2	view →
STAD	Male	II,III,IV	+0.594	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CNPY4–HNSC

Open the HNSC breakdown →