CNPY3

Across TCGA patient cohorts, CNPY3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNPY3-associated genes across cancer lineages are MEK1, PCNA, and PEA-15_pS116. Each is linked with CNPY3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNPY3-to-partner and partner-to-CNPY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CNPY3-low versus CNPY3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNPY3→partner) and Y-score (partner→CNPY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.512	+3.169	.005	.019	3	1
UCEC	PCNA →	+0.290	+2.321	.007	.035	3	1
UCEC	PEA-15_pS116 →	+0.475	+2.321	.007	.035	3	1
UCEC	Src_pY527 →	-0.506	-2.321	.019	.035	3	1
UCEC	VHL →	-1.010	-2.321	.003	.035	3	1
UCEC	ATM →	-0.929	-2.321	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MEK1 by CNPY3 expression — UCEC

Explore this box plot interactively →