CNPY3

Across TCGA pan-cancer cohorts, CNPY3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CNPY3 data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CNPY3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CNPY3 expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUAD show a favorable association.

COAD, ACC, and KIRC are the cancer types where CNPY3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.426	0.603	<.001	74	view →
ACC	DFS	Tertile	All	0.227	0.756	<.001	74	view →
KIRC	DFS	Quartile	All	0.825	0.915	<.001	60	view →
SCLC	DFS	Median	II,III,IV	0.782	0.399	<.001	59	view →
LGG	DFS	Median	All	0.299	0.494	<.001	52	view →
LUAD	DFS	Tertile	II,III,IV	0.631	0.366	.006	36	view →
LUSC	OS	Median	All	0.831	0.603	.001	26	view →
LIHC	OS	Tertile	All	0.736	0.898	.001	21	view →
THYM	OS	Quartile	All	1.000	0.661	.006	18	view →
BRCA	DFS	Quartile	All	0.686	0.430	.004	16	view →
KICH	DFS	Tertile	II,III,IV	0.538	1.000	.014	14	view →
PAAD	DFS	Quartile	II,III,IV	0.542	0.243	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CNPY3–COAD (DFS)

Open the COAD breakdown →