CNPY3

Across TCGA pan-cancer cohorts, CNPY3 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of CNPY3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CNPY3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CNPY3 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where CNPY3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNPY3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.987	<.001	12	view →
HNSC	Male	III,IV	+1.309	<.001	11	view →
KIRP	All	II,III,IV	+1.139	<.001	11	view →
COAD	Male	III,IV	+1.086	<.001	11	view →
KICH	Female	II,III,IV	−1.731	<.001	8	view →
STAD	Male	II,III,IV	+1.301	<.001	8	view →
UCEC	All	All	+0.622	<.001	6	view →
BRCA	All	All	+0.508	<.001	6	view →
ESCA	All	All	+1.053	.004	4	view →
READ	All	All	+0.477	.001	4	view →
LIHC	All	All	+0.475	<.001	4	view →
LUSC	All	All	+0.274	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

CNPY3–KIRC

Open the KIRC breakdown →