CNOT9

Across TCGA patient cohorts, CNOT9 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT9-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, VEGFR2, and VHL. Each is linked with CNOT9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT9-to-partner and partner-to-CNOT9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by CNOT9-low versus CNOT9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT9→partner) and Y-score (partner→CNOT9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.535	+2.817	.044	.036	3	1
UCEC	VEGFR2 →	+0.434	+2.183	.005	.035	3	1
UCEC	VHL →	-1.059	-3.321	.002	.010	2	1
UCEC	c-Jun_pS73 →	-0.206	-3.321	.013	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Acetyl-a-Tubulin-Lys40 by CNOT9 expression — UCEC

Explore this box plot interactively →