CNOT9

Across TCGA pan-cancer cohorts, CNOT9 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CNOT9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CNOT9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CNOT9 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where CNOT9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNOT9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.688	<.001	12	view →
COAD	Female	II,III,IV	+1.030	<.001	11	view →
HNSC	Male	III,IV	+0.956	<.001	11	view →
BLCA	Male	III,IV	+0.822	<.001	11	view →
LUAD	Male	II,III,IV	+0.663	<.001	10	view →
LIHC	All	III,IV	+1.192	<.001	9	view →
STAD	Female	All	+1.249	<.001	8	view →
LUSC	Female	All	+0.887	<.001	8	view →
KICH	Female	All	−0.668	<.001	8	view →
READ	All	II,III,IV	+0.960	<.001	7	view →
UCEC	All	III,IV	+1.036	<.001	6	view →
BRCA	All	III,IV	+0.612	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CNOT9–KIRC

Open the KIRC breakdown →