CNOT9

Across TCGA pan-cancer cohorts, CNOT9 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated CNOT9 data layer compared with 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CNOT9 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CNOT9 expression acts as an unfavorable survival marker, although some lineages such as HNSC and THYM show a favorable association.

ACC, KIRP, and LIHC are the cancer types where CNOT9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.220	0.674	<.001	144	view →
KIRP	DFS	Median	All	0.790	0.915	<.001	109	view →
LIHC	OS	Median	All	0.613	0.757	<.001	96	view →
MESO	OS	Median	All	0.278	0.486	<.001	80	view →
HNSC	OS	Median	All	0.760	0.608	<.001	44	view →
UVM	DFS	Quartile	All	0.320	0.757	.004	38	view →
LGG	OS	Tertile	All	0.713	0.888	<.001	34	view →
THYM	OS	Median	All	1.000	0.724	.001	21	view →
SKCM	OS	Quartile	II,III,IV	0.272	0.553	<.001	21	view →
KICH	DFS	Median	III,IV	0.280	0.910	.001	20	view →
LUAD	DFS	Tertile	All	0.722	0.840	.002	20	view →
PAAD	DFS	Quartile	All	0.231	0.616	.002	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

CNOT9–ACC (DFS)

Open the ACC breakdown →