CNOT9

Across TCGA cell cohorts, CNOT9 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,865 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNOT9-associated GO terms across cancer lineages are Replication fork processing, Regulation of DNA damage checkpoint, and Mitotic G2/M transition checkpoint. Each is linked with CNOT9 in more than 19 cancer types. Because this analysis shows association rather than direction, both CNOT9-to-partner and partner-to-CNOT9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Replication fork processing grouped by CNOT9-low versus CNOT9-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT9→partner) and Y-score (partner→CNOT9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Replication fork processing →	+0.147	+0.785	.003	.001	3	20
LUNG_NSCLC_LUSC	Regulation of DNA damage checkpoint →	+0.125	+1.032	<.001	<.001	3	19
BONE	Mitotic G2/M transition checkpoint →	+0.100	+0.619	.003	.005	3	19
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.144	+0.735	.003	.002	3	19
BONE	DNA-templated DNA replication →	+0.160	+0.708	.004	.004	3	19
SKIN	Nuclear chromosome segregation →	+0.115	+0.672	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,865 associations by consensus.

Replication fork processing by CNOT9 expression — BONE

Explore this box plot interactively →