CNOT9

Across TCGA cell cohorts, CNOT9 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNOT9-associated genes across cancer lineages are SIGLEC5, KIR2DS4, and RASGEF1C. Each is linked with CNOT9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT9-to-partner and partner-to-CNOT9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC5 grouped by CNOT9-low versus CNOT9-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT9→partner) and Y-score (partner→CNOT9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SIGLEC5 →	+0.022	+4.415	<.001	.007	3	1
SKIN	KIR2DS4 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	RASGEF1C →	+0.263	+3.333	<.001	.009	3	1
LARGE_INTESTINE	ABCG4 →	+0.255	+3.451	.002	.005	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.200	+4.029	<.001	.001	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SIGLEC5 by CNOT9 expression — SKIN

Explore this box plot interactively →