CNOT1

Across TCGA cell cohorts, CNOT1 mutation is significantly associated with the RNA expression of many other genes, with 1,290 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNOT1-associated genes across cancer lineages are SIGLEC10, KHDC3L, and ACSM4. Each is linked with CNOT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNOT1-to-partner and partner-to-CNOT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC10 grouped by CNOT1-low versus CNOT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT1→partner) and Y-score (partner→CNOT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIGLEC10 →	+0.184	+2.058	<.001	.005	3	3
PANCREAS	KHDC3L →	+0.028	+4.035	<.001	.003	3	2
PANCREAS	ACSM4 →	+0.035	+4.209	<.001	.002	3	2
LUNG_NSCLC_LUAD	DPPA2 →	+0.812	+3.819	.007	.001	3	2
LARGE_INTESTINE	NIBAN3 →	+0.190	+2.160	<.001	.001	3	2
LUNG_NSCLC_LUAD	ACER1 →	+0.042	+3.180	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,290 associations by consensus.

SIGLEC10 by CNOT1 expression — LARGE_INTESTINE

Explore this box plot interactively →