CNOT1

Across TCGA pan-cancer cohorts, CNOT1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CNOT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CNOT1 RNA is repressed in tumor relative to normal tissue. In most cancer types CNOT1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, BLCA, and LIHC are the cancer types where CNOT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNOT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.827	<.001	8	view →
BLCA	All	All	+0.532	.001	8	view →
LIHC	All	All	+0.736	<.001	7	view →
LUSC	Male	All	+0.540	<.001	5	view →
CHOL	Male	All	+1.759	<.001	4	view →
KIRP	Female	II,III,IV	+0.974	<.001	3	view →
LUAD	All	All	+0.338	.001	3	view →
PAAD	Male	All	+0.550	.018	2	view →
HNSC	All	All	+0.396	.020	2	view →
COAD	All	All	+0.232	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CNOT1–THCA

Open the THCA breakdown →