CNNM1

Across TCGA cell cohorts, CNNM1 mutation is significantly associated with the RNA expression of many other genes, with 937 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNNM1-associated genes across cancer lineages are CISD2, PPM1M, and NUDT6. Each is linked with CNNM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNNM1-to-partner and partner-to-CNNM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CISD2 grouped by CNNM1-low versus CNNM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNNM1→partner) and Y-score (partner→CNNM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CISD2 →	+0.502	+2.265	.004	.001	3	2
LARGE_INTESTINE	PPM1M →	+0.753	+3.584	.002	<.001	3	2
LARGE_INTESTINE	NUDT6 →	+0.826	+3.649	<.001	<.001	3	2
SKIN	SLC17A1 →	+0.005	+3.700	<.001	.009	3	1
SKIN	GPR42 →	+0.063	+2.994	.005	.006	3	1
SKIN	GPR119 →	+0.021	+3.518	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 937 associations by consensus.

CISD2 by CNNM1 expression — LARGE_INTESTINE

Explore this box plot interactively →