CNNM1

Across TCGA pan-cancer cohorts, CNNM1 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated CNNM1 data layer compared with 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CNNM1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CNNM1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and LGG show a favorable association.

LUAD, KIRP, and SKCM are the cancer types where CNNM1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.562	0.789	<.001	80	view →
KIRP	OS	Median	III,IV	0.798	0.512	.005	56	view →
SKCM	OS	Tertile	IV	0.465	0.896	.005	46	view →
LGG	DFS	Quartile	All	0.843	0.667	<.001	37	view →
LAML	DFS	Median	All	0.247	0.511	<.001	36	view →
KICH	OS	Quartile	III,IV	0.173	0.820	.001	27	view →
THCA	OS	Tertile	IV	0.514	0.924	.006	22	view →
LUSC	OS	Quartile	All	0.813	0.555	.014	21	view →
TGCT	DFS	Quartile	All	0.406	0.759	.008	18	view →
ACC	DFS	Median	IV	0.495	0.066	.001	15	view →
BRCA	DFS	Quartile	IV	0.355	0.916	.013	14	view →
UCEC	OS	Quartile	All	0.802	0.901	.007	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

CNNM1–LUAD (DFS)

Open the LUAD breakdown →