CNMD

Across TCGA patient cohorts, CNMD mutation is significantly associated with the RNA expression of many other genes, with 492 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNMD-associated genes across cancer lineages are RN7SKP109, MBD3L2, and ERHP2. Each is linked with CNMD in more than 1 cancer types. Because this analysis shows association rather than direction, both CNMD-to-partner and partner-to-CNMD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP109 grouped by CNMD-low versus CNMD-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNMD→partner) and Y-score (partner→CNMD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP109 →	+0.203	+5.646	<.001	.004	3	2
LUAD	MBD3L2 →	+0.071	+4.122	.007	.009	3	2
SKCM	ERHP2 →	+0.037	+3.897	<.001	.009	3	2
UCEC	KCNK15 →	-1.478	-3.700	<.001	.001	3	2
UCEC	IL9 →	+0.110	+2.536	<.001	.004	3	2
COAD	RNU6-694P →	+0.523	+5.893	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 492 associations by consensus.

RN7SKP109 by CNMD expression — BRCA

Explore this box plot interactively →