CNMD

Across TCGA pan-cancer cohorts, CNMD RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CNMD data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher CNMD RNA is associated with better overall survival. In most high-consensus cancer types, elevated CNMD expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUAD show a favorable association.

SCLC, LGG, and LUAD are the cancer types where CNMD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	II,III,IV	0.721	0.301	<.001	46	view →
LGG	OS	Median	All	0.738	0.879	<.001	44	view →
LUAD	DFS	Quartile	All	0.881	0.745	<.001	43	view →
READ	OS	Tertile	III,IV	0.693	0.254	.003	34	view →
LUSC	OS	Tertile	II,III,IV	0.903	0.489	.001	20	view →
UCS	DFS	Quartile	II,III,IV	0.755	0.220	.002	18	view →
MESO	OS	Median	II,III,IV	0.318	0.728	.014	18	view →
PCPG	DFS	Median	All	1.000	0.788	<.001	15	view →
BLCA	OS	Quartile	All	0.307	0.525	.008	13	view →
SKCM	DFS	Tertile	III,IV	0.427	0.661	.005	12	view →
PRAD	DFS	Quartile	All	0.864	0.696	.011	12	view →
ESCA	DFS	Median	All	0.425	0.573	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CNMD–SCLC (OS)

Open the SCLC breakdown →