CMC4

Across TCGA patient cohorts, CMC4 protein abundance is significantly associated with the RNA expression of many other genes, with 12,456 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CMC4-associated genes across cancer lineages are BUB1B, MCM10, and SPAG5. Each is linked with CMC4 in more than 5 cancer types. Because this analysis shows association rather than direction, both CMC4-to-partner and partner-to-CMC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CMC4 versus BUB1B in LUAD, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMC4→partner) and Y-score (partner→CMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BUB1B →	-0.809	-0.470	.001	.001	3	6
BRCA	MCM10 →	-1.043	-0.611	<.001	<.001	3	5
LUAD	SPAG5 →	-0.666	-0.382	.009	.007	3	5
BRCA	SYBU →	+1.283	+0.504	<.001	<.001	3	4
LSCC	SPINDOC →	-0.493	-0.343	<.001	<.001	3	4
OV	FAM3A →	+0.645	+0.630	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,456 associations by consensus.

CMC4 vs BUB1B — LUAD

Explore this scatter interactively →