CMC4

Across TCGA pan-cancer cohorts, CMC4 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of CMC4’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where CMC4 RNA is repressed in tumor relative to normal tissue. In most cancer types CMC4 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.

STAD are the cancer types where CMC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CMC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	All	−0.120	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

CMC4–STAD

Open the STAD breakdown →