CLUH

Across TCGA patient cohorts, CLUH protein abundance is significantly associated with the RNA expression of many other genes, with 18,675 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLUH-associated genes across cancer lineages are C1QBP, ATXN1, and FLI1. Each is linked with CLUH in more than 8 cancer types. Because this analysis shows association rather than direction, both CLUH-to-partner and partner-to-CLUH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLUH versus C1QBP in UCEC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLUH→partner) and Y-score (partner→CLUH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C1QBP →	+0.973	+0.370	<.001	<.001	3	9
BRCA	ATXN1 →	-0.775	-0.402	<.001	<.001	3	8
BRCA	FLI1 →	-0.749	-0.393	<.001	<.001	3	8
LSCC	FRZB →	-1.054	-0.374	<.001	<.001	3	8
COAD	LMOD1 →	-1.150	-0.410	.001	<.001	3	8
BRCA	ZCCHC24 →	-0.824	-0.261	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,675 associations by consensus.

CLUH vs C1QBP — UCEC

Explore this scatter interactively →