CLUH

Across TCGA pan-cancer cohorts, CLUH RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CLUH’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CLUH RNA is repressed in tumor relative to normal tissue. In most cancer types CLUH is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, STAD, and LUSC are the cancer types where CLUH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLUH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.767	<.001	9	view →
STAD	All	II,III,IV	+0.977	<.001	8	view →
LUSC	Male	III,IV	+1.787	<.001	7	view →
UCEC	All	All	+0.612	.009	6	view →
LUAD	All	III,IV	+0.533	.016	3	view →
COAD	Female	All	+0.371	.034	2	view →
KIRC	Male	All	−0.360	.014	2	view →
CHOL	All	All	+0.336	.018	2	view →
LIHC	All	All	+0.286	.004	2	view →
BRCA	Female	All	−0.206	.029	2	view →
BLCA	Female	III,IV	+0.604	.034	1	view →
KIRP	Female	All	+0.490	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CLUH–THCA

Open the THCA breakdown →