CLUH

Across TCGA pan-cancer cohorts, CLUH RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CLUH data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CLUH RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLUH expression acts as an unfavorable survival marker, although some lineages such as SCLC and READ show a favorable association.

UVM, SCLC, and KICH are the cancer types where CLUH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.395	0.739	.003	63	view →
SCLC	OS	Median	All	0.734	0.410	<.001	57	view →
KICH	OS	Tertile	All	0.665	1.000	.007	34	view →
READ	OS	Median	III,IV	1.000	0.449	.004	32	view →
SKCM	OS	Tertile	All	0.267	0.403	.001	31	view →
KIRC	DFS	Median	All	0.771	0.477	<.001	30	view →
LUAD	DFS	Quartile	All	0.736	0.884	.002	25	view →
SARC	OS	Tertile	All	0.430	0.868	<.001	21	view →
OV	OS	Tertile	All	0.810	0.871	.009	20	view →
THCA	DFS	Median	III,IV	0.749	0.946	.006	17	view →
BRCA	OS	Quartile	II,III,IV	0.865	0.938	.004	17	view →
GBM	DFS	Tertile	All	0.431	0.175	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CLUH–UVM (DFS)

Open the UVM breakdown →