CLUH

Across TCGA patient cohorts, CLUH mutation is significantly associated with the RNA expression of many other genes, with 5,899 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLUH-associated genes across cancer lineages are CHAF1A, MRM3, and CTDNEP1. Each is linked with CLUH in more than 3 cancer types. Because this analysis shows association rather than direction, both CLUH-to-partner and partner-to-CLUH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1A grouped by CLUH-low versus CLUH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLUH→partner) and Y-score (partner→CLUH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1A →	+0.499	+1.571	<.001	<.001	3	4
COAD	MRM3 →	+0.401	+1.778	.001	.008	3	4
COAD	CTDNEP1 →	+0.383	+3.335	<.001	<.001	3	4
COAD	PSMB6 →	+0.380	+3.551	.001	.002	3	4
COAD	SERP2 →	-0.869	-2.311	<.001	.005	3	3
STAD	FGD5 →	-0.856	-3.289	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,899 associations by consensus.

CHAF1A by CLUH expression — UCEC

Explore this box plot interactively →