CLUH

Across TCGA patient cohorts, CLUH mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CLUH-associated genes across cancer lineages are GSK-3_pS9, GSK-3a-b_pS21_S9, and c-Kit. Each is linked with CLUH in more than 2 cancer types. Because this analysis shows association rather than direction, both CLUH-to-partner and partner-to-CLUH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by CLUH-low versus CLUH-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLUH→partner) and Y-score (partner→CLUH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	GSK-3_pS9 →	-0.449	-3.321	.007	.009	3	3
STAD	GSK-3a-b_pS21_S9 →	-0.393	-2.321	.010	.034	3	3
STAD	c-Kit →	-0.340	-2.321	.017	.032	3	3
STAD	4E-BP1 →	+0.300	+2.321	.026	.034	3	3
COAD	eIF4E →	+0.211	+2.182	.001	.033	3	3
COAD	Caveolin-1 →	-0.693	-3.169	.010	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

GSK-3_pS9 by CLUH expression — STAD

Explore this box plot interactively →