CLUH

Across TCGA cell cohorts, CLUH mutation is significantly associated with the RNA expression of many other genes, with 545 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLUH-associated genes across cancer lineages are OR11H12, ODF4, and SSMEM1. Each is linked with CLUH in more than 1 cancer types. Because this analysis shows association rather than direction, both CLUH-to-partner and partner-to-CLUH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H12 grouped by CLUH-low versus CLUH-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLUH→partner) and Y-score (partner→CLUH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR11H12 →	+0.058	+4.222	<.001	.007	3	2
KIDNEY	ODF4 →	+0.030	+5.000	<.001	.005	3	2
BREAST	SSMEM1 →	+0.090	+3.750	<.001	.007	3	2
PANCREAS	NEUROG1 →	+0.032	+4.614	<.001	.004	3	1
PANCREAS	ADH1B →	+0.760	+4.491	<.001	.003	3	1
PANCREAS	TCP11X1 →	+0.005	+4.614	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 545 associations by consensus.

OR11H12 by CLUH expression — SOFT_TISSUE

Explore this box plot interactively →