CLTRN

Across TCGA patient cohorts, CLTRN mutation is significantly associated with the RNA expression of many other genes, with 908 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLTRN-associated genes across cancer lineages are RNU6-383P, RN7SL82P, and MIR6130. Each is linked with CLTRN in more than 1 cancer types. Because this analysis shows association rather than direction, both CLTRN-to-partner and partner-to-CLTRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-383P grouped by CLTRN-low versus CLTRN-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLTRN→partner) and Y-score (partner→CLTRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-383P →	+0.771	+6.309	<.001	.001	3	2
BRCA	RN7SL82P →	+0.113	+7.731	<.001	.009	3	1
BRCA	MIR6130 →	+0.403	+8.471	<.001	.005	3	1
UCEC	MIR6129 →	+0.560	+2.496	<.001	.001	3	1
UCEC	TAF9 →	+0.616	+3.700	.001	.001	3	1
UCEC	MIR6514 →	-0.755	-3.689	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 908 associations by consensus.

RNU6-383P by CLTRN expression — LUSC

Explore this box plot interactively →